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Iterative Crystallography Service:Pyrroline-5-carboxylate Reductase 1 (CBCRY27)

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Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymat ...

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Iterative Crystallography Service:Enolase-phosphatase E1 (CBCRY26)

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Enolase-phosphatase E1 (MASA) is a bifunctional enzyme in the ubiquitous methionine salvage pathway that catalyzes the continuous reactions of 2,3-diketo-5-methylthio-1-phosphopentane to yield the aci ...
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Iterative Crystallography Service:Pyrroline-5-carboxylate Reductase 2 (CBCRY25)

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Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymat ...

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Iterative Crystallography Service:Porphobilinogen deaminase (CBCRY24)

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The protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this ge ...

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Iterative Crystallography Service:Periplasmic Binding Transport Protein (CBCRY22)

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The crystal structure of a periplasmic l-aspartate/l-glutamate binding protein (DEBP) from Shigella flexneri complexed with an l-glutamate molecule has been determined and refined to an atomic resolut ...

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Iterative Crystallography Service:Diamine Acetyltransferase 1 (CBCRY21)

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Spermidine/spermine N(1)-acetyltransferase (SSAT; EC 2.3.1.57) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine ...

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Iterative Crystallography Service:Chloride intracellular channel 4 (CBCRY20)

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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellul ...

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Iterative Crystallography Service:Pyridoxal kinase (CBCRY19)

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Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5'-phosphate, a ke ...
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Iterative Crystallography Service:The neurotrophin-3 and p75NTR symmetrical (CBCRY18)

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Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: t ...
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Iterative Crystallography Service:Guanosine monophosphate reductase 2 (CBCRY17)

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Guanosine monophosphate reductase (GMPR) Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G ...
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Iterative Crystallography Service:Thioesterase superfamily member 2 (CBCRY16)

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The crystallographic structure of recombinant hTHEM2, determined by the single-wavelength anomalous dispersion method at 2.3A resolution, demonstrates that hTHEM2 indeed contains a hotdog-fold and for ...
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Iterative Crystallography Service:Coactosin-like protein (CBCRY15)

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Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulatin ...
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Iterative Crystallography Service:Mu-crystallin homolog (CBCRY14)

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Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of v ...
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Iterative Crystallography Service:Bisphosphoglycerate mutase (BPGM)

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Bisphosphoglycerate mutase is an erythrocyte-specific enzyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3-bisphosphoglycerate, the ...
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Iterative Crystallography Service:Eukaryotic translation initiation factor 3 subunit K (CBCRY12)

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eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including ...

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Iterative Crystallography Service:Phosphoglycerate Mutase 1 (CBCRY11)

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The B-type cofactor-dependent phosphoglycerate mutase (dPGM-B) catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways using 2,3-bisphosph ...
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Iterative Crystallography Service:Isopentenyl-diphosphate delta-isomerase 1 (CBCRY10)

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IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the s ...
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Iterative Crystallography Service:WD-repeat protein 5 (CBCRY09)

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The WD40 repeat protein WDR5 specifically associates with the K4-methylated histone H3 in human cells. The structure of WDR5 in complex with a dimethylated H3-K4 peptide was deterimined. Unlike the ch ...
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Iterative Crystallography Service:Potassium channel Kv4.3 with regulatory subunit KChIP1 (CBCRY08)

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The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. Th ...
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Iterative Crystallography Service:Embryonic Ectoderm Development (CBCRY07)

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The crystal structure of EED in complex with a 30 residue peptide from EZH2 reveals that the peptide binds to the bottom of the WD-repeat domain of EED. The structural determinants of EZH2-EED interac ...
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